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Wednesday, October 7, 2020 | History

3 edition of Retinoids, differentiation, and disease. found in the catalog.

Retinoids, differentiation, and disease.

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  • 31 Currently reading

Published by Pitman, Distributed in North America by CIBA Pharmaceutical Co. in London, Newark, NJ, USA .
Written in English

    Subjects:
  • Retinoids -- Physiological effect -- Congresses.,
  • Retinoids -- Therapeutic use -- Congresses.,
  • Cell differentiation -- Congresses.,
  • Cancer -- Chemotherapy -- Congresses.

  • Edition Notes

    SeriesCiba Foundation symposium ;, 113
    ContributionsCiba Foundation., Symposium on Retinoids, Differentiation, and Disease (1984 : London, England)
    Classifications
    LC ClassificationsQP801.R47 R48 1985
    The Physical Object
    Paginationx, 286 p. :
    Number of Pages286
    ID Numbers
    Open LibraryOL2637406M
    ISBN 100272798134
    LC Control Number85211988

    leukernic cell lines HL and U with retinoic acid for differentiation effects of cyclic adenosine 3':5'-monophosphate-inducing agents and a T-lympho- cyte-derived differentiation factor. Inflammatory causes of DAH (eg, rheumatic diseases, differentiation [retinoic acid] syndrome, and some drug-induced) are typically treated with systemic glucocorticoids, with Treatment of relapsed or refractory acute myeloid leukemia View in Chinese.

      The modulation of epidermal differentiation by retinoids led to its use in premalignant lesions, such as actinic keratoses (Verschoore et al., ). Adapalene is considered to be a second. Retinoids, such as all-trans-retinoic acid (ATRA) (Figure 1), make up a class of endogenous small molecules derived from or functionally related to vitamin A. These compounds exert a significant influence on a wide range of cellular processes in chordates, including differentiation, proliferation, apoptosis, and homeostasis, by regulating transcriptional control in the cell nucleus.

    Systemic retinoids are teratogenic and have to be prescribed with caution and close oversight. Other potential adverse events are controversial. These include the relationship of retinoid derivatives in sunscreens, their effects on bone mineral density, depression and suicidal ideation and inflammatory bowel disease. Oral retinoids are taken after meals to maximise the absorption as they are lipid-soluble. Detailed dosage and treatment duration depend on the individual product and disease [4,6,9] Women of reproductive age must not take oral retinoid therapy unless effective contraception is established (eg, a long-acting reversible contraceptive).


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Retinoids, differentiation, and disease Download PDF EPUB FB2

The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases differentiation therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical : $ The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Retinoids are valuable drugs in the dermatologic armamentarium, being employed in daily clinical practice. The text provides an in-depth update on the latest thinking on pharmacology, clinical use, side Retinoids, and follow-up differentiation retinoid therapy in dermatology; it also addresses topics and disease.

book to retinoid use in special circumstances, such as vulnerable populations, concomitant. This volume contains a comprehensive collection of methods for the isolation of platelet membranes, subcellular organelles, the cytoskeleton, and for the assay and purification of platelet receptors.

Key Features* Platelets are cellular elements with the highest density of receptors per membrane surface area involved in binding of adhesive molecules, clotting, enzymes, and vasoactive amines. Retinoids are valuable drugs in the dermatologic armamentarium, being employed in daily clinical practice.

The text provides an in-depth update on the latest thinking on pharmacology, clinical use, side effects, and follow-up of retinoid therapy in dermatology; it also addresses topics related to retinoid use in special circumstances, such as vulnerable populations, concomitant surgery, and Author: Ayse Serap Karadag, Berna Aksoy, Lawrence Charles Parish.

This symposium deals with the fundamental role of retinoids in the control of cell differentiation and cell proliferation, and the application of this know- ledge to the understanding and treatment of human disease.

It is clear that research on retinoids has expanded far beyond its original domain of studies of nutrition and vision.

Book Description. This reference provides a comprehensive overview of recent developments in basic research that are relevant to the application of retinoids for cancer prevention and treatment.;Organized in a quick-referral format by specific disease site, this book: describes the effects of retinoids on squamous differentiation in normal, pre-malignant, and malignant epithelial tissues.

Retinoic acid (RA) signaling pathways regulate essential biological functions, such as cell development, differentiation, proliferation, and apoptosis, and the expression of retinoid receptors is downregulated in several tumor types [4,10,14,15].RA signaling is crucial for mammalian post-implantation development and organogenesis, and vitamin A deficiency is associated with embryo and fetal.

Title: Recent Advances in the Mechanisms of Action and Physiological Functions of the Retinoid-Related Orphan Receptors (RORs) VOLUME: 3 ISSUE: 4 Author(s):Anton M.

Jetten Affiliation:Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NCUSA. Abstract: Retinoids are a class of natural and synthetic vitamin A analogs structurally related to all-trans-retinoic acid (ATRA).

Natural retinoids are involved in the physiology of vision and as morphogenic agents during embryonic development; they are also known to play a major role in regulating growth and differentiation of a wide variety of normal and malignant cell types, and, indeed.

ISBN: OCLC Number: Notes: "Symposium on Retinoids, Differentiation, and Disease, held at the Ciba Foundation, London, September "--Page v. Book: All Authors / Contributors: Ciba Foundation. ISBN: OCLC Number: Notes: "Symposium on Retinoids, Differentiation, and Disease, held at the Ciba Foundation, London, September "--Page v.

Description: x, pages: illustrations ; 24 cm: Contents: What is a retinoid. Retinoic acid, a vitamin A derivative that is used as a differentiation‐inducing agent in neuroblastoma treatment, is considered standard of care for children with high‐risk disease.

31 - 33 Nevertheless, it is not uniformly beneficial for all patients. Books Go Search EN Hello, Sign in Account & Lists Sign in Account & Lists Orders Try Prime Cart. Best Sellers Gift Ideas New Releases Whole Foods Today's Deals. The vitamin A (retinol) metabolite, all-trans retinoic acid (RA), is a signaling molecule that plays key roles in the development of the body plan and induces the differentiation of many types of cells.

In this review the physiological and pathophysiological roles of retinoids (retinol and related metabolites) in mature animals are discussed. The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy.

Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic. Heather F.

Bigg, Tim E. Cawston, Effect of retinoic acid in combination with platelet‐derived growth factor‐BB or transforming growth factor‐β on tissue inhibitor of metalloproteinases and collagenase secretion from human skin and synovial fibroblasts, Journal of Cellular Physiology, /(SICI)()AID-JCP10> Vitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation, organogenesis, and reproduction and a key role in mucosal immune responses.

RA promotes dendritic cells to express CD and to produce RA, enhances the differentiation of Foxp3 + inducible regulatory T cells, and induces gut-homing specificity in T cells. In the future' the decade of the s will likely be viewed as a Golden Age for retinoid research.

There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of retinoic acid in develop­ mental processes was first broadly recognized in the late s.

Retinoid-related orphan receptors (RORs): Roles in cell survival, differentation and disease Article (PDF Available) in Cell Death and Differentiation 9(11) December with Reads. Retinoic acid (RA), a derivative of vitamin A, is critical for the production of oocytes and sperm in mammals.

These gametes derive from primordial germ cells, which colonize the nascent gonad, and later undertake sexual differentiation to produce oocytes or sperm. During fetal development, germ cells in the ovary initiate meiosis in response to RA, whereas those in the testis do not yet.As an innovation of this FASEB SRC on Retinoids, the meeting kicked off with a roundtable panel discussion consisting of 8 panelists—W.

Blaner (Columbia University, New York, NY, USA), E. Dmitrovsky (MD Anderson Cancer Center, Houston, TX, USA), E.

Harrison (Ohio State University, Columbus, OH, USA), J. Napoli (University of California–Berkeley, Berkeley, CA, USA), N. Noy (Case .Retinoids are particularly attractive agents for the treatment of podocyte disease, as it has been demonstrated that following podocyte injury, both decrease podocyte proliferation and maintain the expression of markers of differentiation.The promoter region of the human nephrin gene (NPHS1) contains three putative retinoic acid.